Medicinal Properties of Boron Supplementation on the Prevention and Treatment of Diseases: A Systematic Review

Objective Boron supplement is an essential ingredient for humans approved the American Food and Drug Administration. Since today, the use of dietary supplements for the treatment of diseases has received much attention, this systematic review study aimed to determine the effect of boron supplement on the treatment and prevention of various diseases. Methods The search was conducted among papers published until July 2019 and indexed in Web of Science, Scopus, PubMed, Science Direct, Google Scholar, SID, IranMedex and MagIran databases using keywords of “boron supplementation”, “boric acid”, “calcium fructoborate”, “treatment”, and “prevention”. Articles with a score of 3 or more based on the Jadad Scale were included in the study (n=67).  Results Fifteen preventive therapeutic effects of boron supplement were investigated. All studies confirmed the favorable effect of boron supplementation in the fields of treatment and prevention and no side effects were reported in any of them. Conclusion Symptoms of boron deficiency such as amnesia, osteoporosis, degenerative diseases, hormonal disorders and decreased libido are prevalent, and this deficiency have many side effects that can be prevented. Hence, the use of boron as a reasonable nutritional intervention and appropriate alternative to conventional chemical drugs is recommended.